Search results for "Viruslike particle"

showing 2 items of 2 documents

Noroviral P-Particles as an In Vitro Model to Assess the Interactions of Noroviruses with Probiotics

2014

Noroviruses (NoVs) are the main etiologic agents of acute epidemic gastroenteritis and probiotic bacteria have been reported to exert a positive effect on viral diarrhea. The protruding (P) domain from NoVs VP1 capsid protein has the ability to assemble into the so-called P-particles, which retain the binding ability to host receptors. We purified the P-domains from NoVs genotypes GI.1 and GII.4 as 6X(His)-tagged proteins and determined that, similar to native domains, they were structured into P-particles that were functional in the recognition of the specific glycoconjugated receptors, as established by surface plasmon resonance experiments. We showed that several lactic acid bacteria (pr…

Applied Microbiologylcsh:Medicinemedicine.disease_causeBiochemistrylaw.inventionProbioticGastrointestinal tractlawLactobacillusGram Negativelcsh:ScienceReceptorMultidisciplinarybiologyBacterial PathogensGastroenteritisHost-Pathogen InteractionLacticaseibacillus caseiHost-Pathogen InteractionsMedicineReceptors VirusBacterial and Foodborne IllnessHT29 CellsGram negative bacteriaResearch ArticleProtein BindingLactobacillus caseiGram-negative bacteriaVirus AttachmentGastroenterology and HepatologyMicrobiologyMicrobiologyVirologyViruslike ParticlesEscherichia colimedicineHumansProtein InteractionsBiologyEscherichia coliProbioticsNoroviruslcsh:RHealth careProteinsCell bindingBacteriologySurface Plasmon Resonancebiology.organism_classificationVirologyIn vitroLactobacillusEnterocytesCapsid Proteinslcsh:QBacteria
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Viral Entry and Receptors

2007

Viruslike particlechemistry.chemical_compoundCapsidchemistryViral entryHeparan sulfateBiologyReceptorVirology
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